Carotenoids located in human lymphocyte subpopulations and natural killer cells by Raman microspectroscopy

Puppels, G.J. and Garritsen, H.S.P. and Kummer, J.A. and Greve, Jan (1993) Carotenoids located in human lymphocyte subpopulations and natural killer cells by Raman microspectroscopy. Cytometry Part A, 14 (3). pp. 251-256. ISSN 0196-4763

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Abstract:	The presence and subcellular location of carotenoids in human lymphocyte sub-populations (CD4+, CD8+, T-cell receptor-γδ+, and CD19+ ) and natural killer cells (CD16+ ) were studied by means of Raman microspectroscopy. In CD4+ lymphocytes a high concentration (10-3M) of carotenoids was found in the Gall body. In CD8+ lymphocytes, T-cell-receptor-γδ+ lymphocytes and in natural killer cells carotenoids appeared to be concentrated (10-4M) in the Golgi complex. The concentration of carotenoids in CD19+ lymphocytes was found to be below the present detection limit, which is ~10-6 to 10-5 M. The results provide new possibilities to investigate the mechanism(s) behind the suggested protective role of carotenoids against the development of cancers.
Item Type:	Article
Copyright:	© 1993 Wiley-Liss
Research Group:	Biophysical Techniques (BFT)
Link to this item:	http://purl.utwente.nl/publications/60728
Official URL:	http://dx.doi.org/10.1002/cyto.990140303
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