Cellular microtissues spontaneously formed in a microfabricated device for angiongenesis

Le Gac, Séverine and Rivron, Nicolas and Wijnperle , Daniel and Blitterswijk van, Clemens and Berg van den, Albert (2008) Cellular microtissues spontaneously formed in a microfabricated device for angiongenesis. In: 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 12-16 October 2008, San Diego, CA.

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Abstract:	We report here on a microdevice for the spontaneous and simultaneous formation of microtissues -or microscale spheroids- in a fast, controlled and reproducible way. Spheroids are relevant constructs for tissue engineering applications, and notably for studying the process of angiogenesis which is of crucial importance for both tissue regeneration and understanding/manipulating tumor vascularization. Our microdevices consist of PDMS microwell arrays whose surface properties are optimized (PDMS composition and applied coating agent) for both promoting cellular aggregation into spheroids and facilitating spheroid removal out of the device.
Item Type:	Conference or Workshop Item
Faculty:	Electrical Engineering, Mathematics and Computer Science (EEMCS) Science and Technology (TNW)
Research Group:	Biomedical and Environmental Sensor systems (BIOS) Tissue Regeneration (TR)
Link to this item:	http://purl.utwente.nl/publications/60702
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