Cellular microtissues spontaneously formed in a microfabricated device for angiongenesis


Le Gac, Séverine and Rivron, Nicolas and Wijnperle , Daniel and Blitterswijk, Clemens van and Berg, Albert van den (2008) Cellular microtissues spontaneously formed in a microfabricated device for angiongenesis. In: 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTas 2008, 12-16 October 2008, San Diego, CA, USA (pp. pp. 1165-1167).

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Abstract:We report here on a microdevice for the spontaneous and simultaneous formation of microtissues-or microscale spheroids- in a fast, controlled and reproducible way. Spheroids are relevant constructs for tissue engineering applications, and notably for studying the process of angiogenesis which is of crucial importance for both tissue regeneration and understanding/manipulating tumor vascularization. Our microde-vices consist of PDMS microwell arrays whose surface properties are optimized (PDMS composition and applied coating agent) for both promoting cellular aggrega-tion into spheroids and facilitating spheroid removal out of the device.
Item Type:Conference or Workshop Item
Electrical Engineering, Mathematics and Computer Science (EEMCS)
Science and Technology (TNW)
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