Cellular microtissues spontaneously formed in a microfabricated device for angiongenesis


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Le Gac, Séverine and Rivron, Nicolas and Wijnperle , Daniel and Blitterswijk van, Clemens and Berg van den, Albert (2008) Cellular microtissues spontaneously formed in a microfabricated device for angiongenesis. In: 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 12-16 October 2008, San Diego, CA.

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Abstract:We report here on a microdevice for the spontaneous and simultaneous formation
of microtissues -or microscale spheroids- in a fast, controlled and reproducible way.
Spheroids are relevant constructs for tissue engineering applications, and notably for
studying the process of angiogenesis which is of crucial importance for both tissue
regeneration and understanding/manipulating tumor vascularization. Our microdevices
consist of PDMS microwell arrays whose surface properties are optimized
(PDMS composition and applied coating agent) for both promoting cellular aggregation
into spheroids and facilitating spheroid removal out of the device.
Item Type:Conference or Workshop Item
Faculty:
Electrical Engineering, Mathematics and Computer Science (EEMCS)
Science and Technology (TNW)
Research Group:
Link to this item:http://purl.utwente.nl/publications/60702
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