Transient Binding and Dissipation in Cross-Linked Actin Networks


Lieleg, O. and Claessens, M.M.A.E. and Luan, Y. and Bausch, A.R. (2008) Transient Binding and Dissipation in Cross-Linked Actin Networks. Physical Review Letters, 101 (10). p. 108101. ISSN 0031-9007

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Abstract:In contrast with entangled actin solutions, transiently cross-linked actin networks can provide highly elastic properties while still allowing for local rearrangements in the microstructure-on biological relevant time scales. Here, we show that thermal unbinding of transient cross-links entails local stress relaxation and energy dissipation in an intermediate elasticity dominated frequency regime. We quantify the viscoelastic response of an isotropically cross-linked actin network by experimentally tuning the off rate of the transiently cross-linking molecules, their density, and the solvent viscosity. We reproduce the measured frequency response by a semiphenomenological model that is predicated on microscopic unbinding events.
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Copyright:© 2008 American Physical Society
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