Fast, Ultrasensitive Virus Detection Using a Young Interferometer Sensor

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Ymeti, Aurel and Greve, Jan and Lambeck, Paul V. and Wink, Thijs and Hovell, Stephan W.F.M. van and Beumer, Tom A.M. and Wijn, Robert R. and Heideman, Rene G. and Subramaniam, Vinod and Kanger, Johannes S. (2007) Fast, Ultrasensitive Virus Detection Using a Young Interferometer Sensor. Nano Letters, 7 (2). pp. 394-397. ISSN 1530-6984

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Abstract:We report the application of an integrated optical Young interferometer sensor for ultrasensitive, real-time, direct detection of viruses. We have validated the sensor by detecting herpes simplex virus type 1 (HSV-1), but the principle is generally applicable. Detection of HSV-1 virus particles was performed by applying the virus sample onto a sensor surface coated with a specific antibody against HSV-1. The performance of the sensor was tested by monitoring virus samples at clinically relevant concentrations. We show that the Young interferometer sensor can specifically and sensitively detect HSV-1 at very low concentrations (850 particles/mL). We have further demonstrated that the sensor can specifically detect HSV-1 suspended in serum. Extrapolation of the results indicates that the sensitivity of the sensor approaches the detection of a single virus particle binding, yielding a sensor of unprecedented sensitivity with wide applications for viral diagnostics
Item Type:Article
Copyright:© 2006 American Chemical Society
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Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/59471
Official URL:http://dx.doi.org/10.1021/nl062595n
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Metis ID: 237829