Interaction of ultrasound driven microbubbles and lipid membrane


Marmottant, P.G.M. and Hilgenfeldt, S. (2002) Interaction of ultrasound driven microbubbles and lipid membrane. Journal of the Acoustical Society of America, 112 . p. 2338. ISSN 00012097

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Abstract:Micron-sized bubbles show pronounced oscillations when submitted to
ultrasound, leading to increased scattering and improved echographic contrast.
It has been reported that this excitation can also alter nearby cell
membranes @M. Ward, J. Wu, and J. F. Chiu, Ultrasound Med. Biol. 26,
1169–1175 ~2000!#, and increase the permeability for drug delivery. To
elucidate the mechanisms at work in these sonoporation experiments, we
developed a setup that allows for a controlled study of the interaction of
single microbubbles with single lipid bilayer vesicles. Substituting
vesicles for cell membranes is advantageous because the mechanical properties
of vesicles are well-known. Microscopic observations reveal that
vesicles near a bubble undergo vivid motion, being periodically accelerated
toward and away from the bubble. This ‘‘bouncing’’ of vesicles is a
vivid motion that we attribute to a streaming flow field set up by the
bubble oscillation. Some vesicles undergo dramatic deformations as they
follow the flow, reflecting the high shear rates attained. Break-up of
vesicles could also be observed.
Item Type:Article
Additional information:Abstract only
Copyright:© 2002 Acoustical Society of America
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