Interaction of ultrasound driven microbubbles and lipid membrane

Share/Save/Bookmark

Marmottant, Philippe and Hilgenfeldt, Sascha (2002) Interaction of ultrasound driven microbubbles and lipid membrane. Journal of the Acoustical Society of America, 112 . p. 2338. ISSN 0001-4966

Full text not available from this repository. The author is invited to upload the full text of this publication.

Abstract:Micron‐sized bubbles show pronounced oscillations when submitted to ultrasound, leading to increased scattering and improved echographic contrast. It has been reported that this excitation can also alter nearby cell membranes [M. Ward, J. Wu, and J. F. Chiu, Ultrasound Med. Biol. 26, 1169–1175 (2000)], and increase the permeability for drug delivery. To elucidate the mechanisms at work in these sonoporation experiments, we developed a setup that allows for a controlled study of the interaction of single microbubbles with single lipid bilayer vesicles. Substituting vesicles for cell membranes is advantageous because the mechanical properties of vesicles are well‐known. Microscopic observations reveal that vesicles near a bubble undergo vivid motion, being periodically accelerated toward and away from the bubble. This ‘‘bouncing’’ of vesicles is a vivid motion that we attribute to a streaming flow field set up by the bubble oscillation. Some vesicles undergo dramatic deformations as they follow the flow, reflecting the high shear rates attained. Break‐up of vesicles could also be observed.
Item Type:Article
Additional information:Abstract only
Copyright:© 2002 Acoustical Society of America
Faculty:
Science and Technology (TNW)
Link to this item:http://purl.utwente.nl/publications/58161
Official URL:https://doi.org/10.1121/1.4779446
Export this item as:BibTeX
EndNote
HTML Citation
Reference Manager

 

Repository Staff Only: item control page