Integrated sensor array for on-line monitoring micro bioreactors
Krommenhoek, Erik Eduard (2007) Integrated sensor array for on-line monitoring micro bioreactors. thesis.
|Abstract:||In this thesis the development of a microbioreactor array with integrated sensoss suitable for on-line screening of micro organisms is described. Therefore, an array of 2 micro bioreactors compatible with the 96-well microtiterplate format has been made and tested. The developed system was shown to be suitable for monitoring dissolved oxygen, viable biomass, pH and temperature during batch fermentations of Candida utilis cells using integrated electrochemical sensor arrays. No signal degradation was observed after autoclaving the sensor arrays several times. PDMS microvalves have been developed as to enable expansion of the system with fed-batch functionality and pH control.
|Link to this item:||http://purl.utwente.nl/publications/58086|
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