Protein aggregate deposition and fouling reduction strategies with high-flux silicon nitride microsieves


Gironès, Miriam and Lammertink, Rob G.H. and Wessling, Matthias (2006) Protein aggregate deposition and fouling reduction strategies with high-flux silicon nitride microsieves. Journal of Membrane Science, 273 (1-2). pp. 68-76. ISSN 0376-7388

[img] PDF
Restricted to UT campus only
: Request a copy
Abstract:Membrane morphology is a key factor in fouling. Characteristics such as a very thin selective layer, well-structured pore size and shape, and smooth surfaces would be ideal for low-fouling membranes. Microsieves, inorganic membranes with high and controlled porosity, offer all the previous features. The goal of this study was the investigation of the mechanism behind flux decline in crossflow filtration of bovine serum albumin (BSA) solutions with microsieve membranes. Subsequently, several strategies to reduce flux decline were also analyzed.

The flux decline rate was pH-dependent, with a more severe reduction at pH close to the isoelectric point. In-line pre-filtering of the BSA solution led to stable fluxes, which indicated that pore blocking was responsible for the decrease in performance. Modelling of the filtration data confirmed a complete pore blocking mechanism. At pH where the decline was lower (6.8), water backflushing helped to recover the flux partially. Water forward flushing was only effective at relatively high permeation rates. As an alternative method, permeate backpulsing was investigated. The permeated volume was successfully increased and the flux decrease retarded when backpulsing was applied. If the permeate was backpulsed at higher frequencies, lower fouling rates were achieved, because aggregates could be removed faster from the microsieve surface.
Item Type:Article
Copyright:© 2005 Elsevier B.V.
Science and Technology (TNW)
Research Group:
Link to this item:
Official URL:
Export this item as:BibTeX
HTML Citation
Reference Manager


Repository Staff Only: item control page

Metis ID: 235153