A double-blind study of the efficacy of apomorphine and its assessment in "off-periods in Parkinson's disease


Laar, T. van and Jansen, E.N.H. and Essink, A.W.G. and Neef, C. and Oosterloo, S. (1993) A double-blind study of the efficacy of apomorphine and its assessment in "off-periods in Parkinson's disease. Clinical neurology and neurosurgery, 95 (3). pp. 231-235. ISSN 0303-8467

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Abstract:Five patients with idiopathic Parkinson's disease with severe response fluctuations were selected for a randomized double-blind placebo-controlled study, concerning the clinical effects of subcutaneous apomorphine and its assessment in `off¿-periods. The study was designed as five n = 1 studies, in which every patient was his own control. The effect of apomorphine was studied by using the Columbia rating scale and quantitative assessments, using tapping, walking and pinboard. There was a significant positive effect of apomorphine, in a mean optimal dose of 2.7 mg, with a mean latency of onset of 7.3 min and a mean duration of response of 96 min. After pretreatment with domperidone, no significant adverse effects were observed. Tapping showed the highest correlation with rigidity and bradykinesia. Walking showed a high correlation with stability and gait. Pinboard testing did not give additional information. The first conclusion was that apomorphine proved to be a significantly effective dopamine agonist, proven now also by a double blind placebo-controlled study. Secondly it was concluded that assessment of clinical effect in parkinsonian patients can be performed best by combining the Columbia item tremor with tapping and walking scores.
Item Type:Article
Copyright:© 1993 Elsevier Science
Faculty of Behavioural, Management and Social sciences (BMS)
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Link to this item:http://purl.utwente.nl/publications/57410
Official URL:https://doi.org/10.1016/0303-8467(93)90128-4
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