Chip-based on-line nanospray MS method enabling study of the kinetics of isocyanate derivatization reactions

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Brivio, Monica and Liesener, André and Oosterbroek, R. Edwin and Verboom, Willem and Karst, Uwe and Berg, Albert van den and Reinhoudt, David N. (2005) Chip-based on-line nanospray MS method enabling study of the kinetics of isocyanate derivatization reactions. Analytical Chemistry, 77 (21). pp. 6852-6856. ISSN 0003-2700

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Abstract:The reaction of propyl isocyanate (2), benzyl isocyanate (3), and toluene-2,4-diisocyanate (4) with 4-nitro-7-piperazino-2,1,3-benzoxadiazole (1) to yield the corresponding urea derivatives 5 was carried out in a continuous flow glass microfluidics chip. Real-time monitoring of the derivatization reactions was done by electrospray ionization mass spectrometry, making use of a recently reported modular chip-MS interface. Rate constants of 1.5 × 104, 5.2 × 104, and 2.4 × 104 M-1 min-1 were determined for 2, 3, and 4, respectively. Using macroscale batch conditions, the rate constants are 3-4 times lower. The faster on-chip kinetics is attributed to the more efficient molecular diffusion in the micrometer-sized channel.
Item Type:Article
Copyright:© 2005 American Chemical Society
Faculty:
Science and Technology (TNW)
Electrical Engineering, Mathematics and Computer Science (EEMCS)
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Link to this item:http://purl.utwente.nl/publications/53016
Official URL:http://dx.doi.org/10.1021/ac050817g S0003-2700(05)00817-6
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