Evaluation of the viability of HL60 cells in contact with commonly used microchip materials


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Wolbers, F. and Braak ter, P.M. and Le Gac, S. and Lüttge, R. and Andersson, S.M.H. and Vermes, I. and Berg van den, A. (2005) Evaluation of the viability of HL60 cells in contact with commonly used microchip materials. In: MicroTAS 2005 Conference, October 9-13, 2005, Boston, MA, USA.

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Abstract:This paper presents beneficial data when deciding to perform cell experiments in lab-on- a-chip devices. The choice of material can influence the viability of mammalian cells. PDMS, precoated with serum or not, suits well for HL60 cells, demonstrating the best results in the viability experiments, as expressed as an apoptosis/proliferation ratio < 1. We also looked at other materials, such as native silicon-oxide (SiO2) and borosilicate glass. In the near future other (combinations) of microchip materials will be analyzed for their viability as well as analyzing the effect of mammalian cells on microchip materials in more detail with MALDI-MS.
Item Type:Conference or Workshop Item
Faculty:
Electrical Engineering, Mathematics and Computer Science (EEMCS)
Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/52868
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