Kinetic study of an on-chip isocyanate derivatization reaction by on-line nano-esi ms


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Brivio, M. and Liesner, A. and Oosterbroek, R.E. and Verboom, W. and Karst, U. and Berg, A. van den and Reinhoudt, D.N. (2005) Kinetic study of an on-chip isocyanate derivatization reaction by on-line nano-esi ms. In: MicroTAS 2005 Conference, October 9-13, 2005, Boston, MA, USA (pp. pp. 927-929).

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Abstract:A high-throughput method is presented for the study of reaction kinetics by nano- electrospray ionization mass spectrometry (nano-ESI MS). The reaction of propyl isocyanate (2), benzyl isocyanate (3), and toluene-2,4-diisocyanate (4) with 4-nitro-7- piperazino-2,1,3-benzoxadiazole (NBDPZ) (1) to yield the corresponding urea derivatives (5) was carried out in a continuous flow glass microchip. Real-time monitoring of the reactions was done by nano-ESI MS. Rate constants of 1.6 ␣ 104 M-1 min-1, 5.2 ␣ 104 M-1 min-1, and 2.5 ␣ 104 M-1 min-1 were determined for isocyanate 2, 3 and 4, respectively.
Item Type:Conference or Workshop Item
Faculty:
Science and Technology (TNW)
Electrical Engineering, Mathematics and Computer Science (EEMCS)
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Link to this item:http://purl.utwente.nl/publications/52865
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