Planar Nanoneedles on-chip for intracellular measurements

Emmelkamp, J. and Gardeniers, J.G.E. and Andersson, S.M.H. and Berg van den, A. (2005) Planar Nanoneedles on-chip for intracellular measurements. In: MicroTAS 2005 Conference, October 9–13, 2005, Boston, MA,. USA.

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Abstract:	We present for the first time a functional planar SiN-nanoneedle system for intracellular mass transport and in vivo electrophysiological measurements on-chip. Though several micro- or nanoneedles for cell research have been described in literature, no needles of this small size equipped with nanosized inner channels or electrodes have been reported. A propidium iodide assay verifies the excellent penetration performance of the nanoneedles with diminished leakage from the cell after insertion and release of the needle from HL60- cells. Hollow needles connected to on-chip sub-picoliter electrochemical dosing systems are in development.
Item Type:	Conference or Workshop Item
Faculty:	Science and Technology (TNW) Electrical Engineering, Mathematics and Computer Science (EEMCS)
Research Group:	Mesoscale Chemical Systems (MCS) Biomedical and Environmental Sensor systems (BIOS)
Link to this item:	http://purl.utwente.nl/publications/52862
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