Planar Nanoneedles on-chip for intracellular measurements


Emmelkamp, J. and Gardeniers, J.G.E. and Andersson, S.M.H. and Berg, A. van den (2005) Planar Nanoneedles on-chip for intracellular measurements. In: MicroTAS 2005 Conference, October 9–13, 2005, Boston, MA,. USA (pp. pp. 400-402).

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Abstract:We present for the first time a functional planar SiN-nanoneedle system for intracellular
mass transport and in vivo electrophysiological measurements on-chip. Though several
micro- or nanoneedles for cell research have been described in literature, no needles of this
small size equipped with nanosized inner channels or electrodes have been reported. A
propidium iodide assay verifies the excellent penetration performance of the nanoneedles
with diminished leakage from the cell after insertion and release of the needle from HL60-
cells. Hollow needles connected to on-chip sub-picoliter electrochemical dosing systems
are in development.
Item Type:Conference or Workshop Item
Science and Technology (TNW)
Electrical Engineering, Mathematics and Computer Science (EEMCS)
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