A MALDI-chip integrated system with a monitoring window

Brivio, Monica and Tas, Niels R. and Goedbloed, Martijn H. and Gardeniers, Han J.G.E. and Verboom, Willem and Berg van den, Albert and Reinhoudt, David N. (2005) A MALDI-chip integrated system with a monitoring window. Lab on a Chip, 5 (4). pp. 378-381. ISSN 1473-0197

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Abstract:	The integration of a monitoring port along the microfluidic path of a MALDI-chip integrated device is described. Optimization of the microreactor design allows longer reaction and measuring times. The Schiff base reaction between 4-tert-butylaniline ( 1) and 4-tert-butylbenzaldehyde ( 2) in ethanol was carried out on-chip in the MALDI ionization chamber and the formed imine 3 was detected in real time, demonstrating the feasibility of the monitoring window approach. This preliminary result opens the way to on-chip kinetic studies by MALDI-MS, by opening multiple monitoring windows along the microchannel.
Item Type:	Article
Copyright:	© 2005 Royal Society of Chemistry
Faculty:	Electrical Engineering, Mathematics and Computer Science (EEMCS) Science and Technology (TNW)
Research Group:	Transducers Science and Technology (TST) Mesoscale Chemical Systems (MCS) Molecular Nanofabrication (MNF) Biomedical and Environmental Sensor systems (BIOS)
Link to this item:	http://purl.utwente.nl/publications/52542
Official URL:	http://dx.doi.org/10.1039/b418986h
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