Micromanipulation of endothelial cells: Ultrasound-microbubble-cell interaction

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Wamel van, Annemieke and Bouakaz, Ayache and Versluis, Michel and Jong de, Nico (2004) Micromanipulation of endothelial cells: Ultrasound-microbubble-cell interaction. Ultrasound in Medicine and Biology, 30 (9). pp. 1255-1258. ISSN 0301-5629

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Abstract:Ultrasound (US) in combination with contrast microbubbles has been shown to alter the permeability of cell membranes without affecting cell viability. This permeabilisation feature is used to design new drug delivery systems using US and contrast agents. The underlying mechanisms are still unknown. One hypothesis is that oscillating microbubbles cause cell deformation resulting in enhanced cell membrane permeability. This technical note reveals the interaction between oscillating microbubbles and endothelial cells under a microscope recorded with a fast framing camera at 10 million frames per second. A microbubble expansion of 100% resulted a 2.3-m displacement of the cell membrane. During the insonification, changes of approximately 15% in the cross-sectional distance of the endothelial cells were observed due to microbubble vibrations. In conclusion, the use of such a camera makes it possible to reveal the mechanisms of interactions between ultrasound, microbubbles and cells.
Item Type:Article
Copyright:© 2004 World Federation for Ultrasound in Medicine & Biology
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Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/49963
Official URL:http://dx.doi.org/10.1016/j.ultrasmedbio.2004.07.015
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Metis ID: 223016