Anion complexation by glycocluster thioureamethyl cavitands: novel ESI-MS-based methods for the determination of Ka values

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Oshovsky, Gennady V. and Verboom, Willem and Fokkens, Roel H. and Reinhoudt, David N. (2004) Anion complexation by glycocluster thioureamethyl cavitands: novel ESI-MS-based methods for the determination of Ka values. Chemistry: a European Journal, 10 (11). pp. 2739-2748. ISSN 0947-6539

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Abstract:A series of saccharide-thiourea functionalized cavitands was prepared in good yields (72-86 %) by reaction of a tetrakis(aminomethyl) cavitand with the thiocyanate derivatives of acetylated glucose, galactose, and cellobiose. The anion complexation behavior of the acetylated and deacetylated glycocluster thioureamethyl cavitands was studied with electrospray ionization mass spectrometry (ESI-MS) in acetonitrile and in a 1:1 acetonitrile/water mixture, respectively. All compounds show a preference for Cl-. A linear relationship was found between the square root of the intensity and the concentration of the formed host-guest complex. Based on this relationship, novel methods have been developed to determine Ka values, by means of direct titration and competition experiments.
Item Type:Article
Copyright:© 2004 Wiley InterScience
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Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/49544
Official URL:http://dx.doi.org/10.1002/chem.200305612
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