Serial nonivasive photoacoustic imaging of neovascularization in tumor angiogenesis

Siphanto, R.I. and Thumma, K.K. and Kolkman, R.G.M. and Leeuwen van, T.G. and Mul de, F.F.M. and Neck van, J.W. and Adrichem van, L.N.A. and Steenbergen, W. (2005) Serial nonivasive photoacoustic imaging of neovascularization in tumor angiogenesis. Optics Express, 13 (1). pp. 89-95. ISSN 1094-4087

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Abstract:	We present photoacoustic images of tumor neovascularization obtained over a 10-day period after subcutaneous inoculation of pancreatic tumor cells in a rat. The images were obtained from ultrasound generated by absorption in hemoglobin of short laser pulses at a wavelength of 1064 nm. The ultrasound signals were measured in reflection mode using a single scanning piezodetector, and images were reconstructed with a weighted delay-and-sum algorithm. Three-dimensional data visualize the development and quantify the extent of individual blood vessels around the growing tumor, blood concentration changes inside the tumor and growth in depth of the neovascularized region.
Item Type:	Article
Copyright:	© 2005 Optical Society of America
Faculty:	Science and Technology (TNW)
Research Group:	Biomedical Photonic Imaging (BMPI)
Link to this item:	http://purl.utwente.nl/publications/48864
Official URL:	http://dx.doi.org/10.1002/10.1364/OPEX.13.000089
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Metis ID: 220645