Microfabrication and microfluidics for tissue engineering: state of the art and future opportunities


Andersson, Helene and Berg, Albert van den (2004) Microfabrication and microfluidics for tissue engineering: state of the art and future opportunities. Lab on a Chip, 4 (2). pp. 98-103. ISSN 1473-0197

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Abstract:An introductory overview of the use of microfluidic devices for tissue engineering is presented. After a brief description of the background of tissue engineering, different application areas of microfluidic devices are examined. Among these are methods for patterning cells, topographical control over cells and tissues, and bioreactors. Examples where microfluidic devices have been employed are presented such as basal lamina, vascular tissue, liver, bone, cartilage and neurons. It is concluded that until today, microfluidic devices have not been used extensively in tissue engineering. Major contributions are expected in two areas. The first is growth of complex tissue, where microfluidic structures ensure a steady blood supply, thereby circumventing the well-known problem of providing larger tissue structures with a continuous flow of oxygen and nutrition, and withdrawal of waste products. The second, and probably more important function of microfluidics, combined with micro/nanotechnology, lies in the development of in vitro physiological systems for studying fundamental biological phenomena.
Item Type:Article
Copyright:© 2004 Royal Society of Chemistry
Electrical Engineering, Mathematics and Computer Science (EEMCS)
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Link to this item:http://purl.utwente.nl/publications/47959
Official URL:https://doi.org/10.1039/b314469k
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