Analysis of apoptosis on chip - Why the move to chip technology


Wolbers, Floor and Haanen, Clemens and Andersson, Helene and Berg, Albert van den and Vermes, István (2004) Analysis of apoptosis on chip - Why the move to chip technology. In: Helene Andersson & Albert van den Berg (Eds.), Lab-on-Chips for Cellomics - Micro and Nanotechnologies for Life Sciences. Kluwer Academic Publishers, Dordrecht, pp. 197-224. ISBN 9781402028601

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Abstract:Apoptosis refers to a specific form of programmed cell death, which guarantees the welfare of the whole organism through the elimination of unwanted cells. The duration of apoptosis is short, involves single cells with morphological changes only after the point of no return, ending with phagocytosis without reaction in the neighbour cell. A number of techniques exist to measure cell death, but we still looking for a simple, specific and sensitive technique which offers the possibility to measure apoptosis on single cell level, without staining, in real time, with high-throughput. The Lab-in-a-Cell concept by using chip technology offers such a tool.
Item Type:Book Section
Copyright:© 2004 Springer
Electrical Engineering, Mathematics and Computer Science (EEMCS)
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