Direct measurement of lithium in whole blood using a capillary electrophoresis microchip


Vrouwe, E.X. and Kölling, P. and Lüttge, R. and Berg, A. van den (2004) Direct measurement of lithium in whole blood using a capillary electrophoresis microchip. Nederlands tijdschrift voor klinische chemie en laboratoriumgeneeskunde, 29 (5). pp. 295-296. ISSN 1570-8306

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Abstract:Receiving clinically relevant blood parameters even for off-chip cleaned up sample is a nontrivial analytical problem. Few devices have been developed that
fully exploit combining multiple functions in socalled micro total analysis systems (1, 2). Instead of advanced component integration on chip, here we
demonstrate that the measurement of alkali metals can be performed in a drop of whole blood using an established type of capillary electrophoresis microchip (3-7) by applying the principles of moving boundary electrophoresis. The emphasis will be on the determination of lithium, which is used in the treatment of manic-depressive mood disorders. The low therapeutic index of lithium in blood is critical throughout the treatment and is therefore an ideal candidate for the demonstration of a microchip for self-testing.
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Copyright:© 2004 Nederlandse Vereniging voor Klinische Chemie en Laboratoriumgeneeskunde
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