Chemically driven switches for online detection of pH changes in microfluidic devices

Mela, P. and Onclin, S. and Goedbloed, M.H. and Levi, S.A. and Hulst van, N.F. and Berg van den, A. (2003) Chemically driven switches for online detection of pH changes in microfluidic devices. In: Eurosensors XVII, European Conference on Solid-State Transducers, September 21-24, 2003, Guimaraes, Portugal.

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Abstract:	The internal walls of microfabricated fluidic channels were functionalized with a selfassembled monolayer of Rhodamine B lactam. This molecule has the capability to interconvert between its open fluorescent amide form and the closed non-fluorescent lactam form upon changes of the pH conditions. The interconversion (switch) between the two reversible forms is achieved by addition of an acid or a base and is consistent with a reaction mechanism of the first order. This paper describes the online observation of such fluorescent switch covalently anchored to the channel and proposes this method as a possible sensor for the monitoring of pH changes in microreactors.
Item Type:	Conference or Workshop Item
Faculty:	Electrical Engineering, Mathematics and Computer Science (EEMCS)
Research Group:	Biomedical and Environmental Sensor systems (BIOS)
Link to this item:	http://purl.utwente.nl/publications/46459
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