Silicon micromachined hollow microneedles for transdermal liquid transport


Gardeniers, Han J.G.E. and Lüttge, Regina and Berenschot, Erwin J.W. and Boer, Meint J. de and Yeshurun, Shuki Y. and Hefetz, Meir and Oever, Ronny van 't and Berg, Albert van den (2003) Silicon micromachined hollow microneedles for transdermal liquid transport. Journal of Microelectromechanical Systems, 12 (6). pp. 855-862. ISSN 1057-7157

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Abstract:This paper presents a novel process for the fabrication of out-of-plane hollow microneedles in silicon. The fabrication method consists of a sequence of deep-reactive ion etching (DRIE), anisotropic wet etching and conformal thin film deposition, and allows needle shapes with different, lithography-defined tip curvature. In this study, the length of the needles varied between 150 and 350 micrometers. The widest dimension of the needle at its base was 250 /spl mu/m. Preliminary application tests of the needle arrays show that they are robust and permit skin penetration without breakage. Transdermal water loss measurements before and after microneedle skin penetration are reported. Drug delivery is increased approximately by a factor of 750 in microneedle patch applications with respect to diffusion alone. The feasibility of using the microneedle array as a blood sampler on a capillary electrophoresis chip is demonstrated.
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Copyright:© 2003 IEEE
Science and Technology (TNW)
Electrical Engineering, Mathematics and Computer Science (EEMCS)
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