Geometry-based finite-element modeling of the electrical contact between a cultured neuron and a microelectrode

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Buitenweg, Jan Reinoud and Rutten, Wim L.C. and Marani, Enrico (2003) Geometry-based finite-element modeling of the electrical contact between a cultured neuron and a microelectrode. IEEE Transactions on Biomedical Engineering, 50 (4). pp. 501-509. ISSN 0018-9294

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Abstract:The electrical contact between a substrate embedded microelectrode and a cultured neuron depends on the geometry of the neuron-electrode interface. Interpretation and improvement of these contacts requires proper modeling of all coupling mechanisms. In literature, it is common practice to model the neuron-electrode contact using lumped circuits in which large simplifications are made in the representation of the interface geometry. In this paper, the finite-element method is used to model the neuron-electrode interface, which permits numerical solutions for a variety of interface geometries. The simulation results offer detailed spatial and temporal information about the combined electrical behavior of extracellular volume, electrode-electrolyte interface and neuronal membrane.
Item Type:Article
Copyright:©2003 IEEE
Faculty:
Electrical Engineering, Mathematics and Computer Science (EEMCS)
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Link to this item:http://purl.utwente.nl/publications/45548
Official URL:http://dx.doi.org/10.1109/TBME.2003.809486
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