Survival of adhering cortical neurons on polyethylenimine micropatterns

Ruardij, T.G. and Goedbloed, M.H. and Rutten, W.L.C. (2001) Survival of adhering cortical neurons on polyethylenimine micropatterns. In: 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Isyanbul, Turkey.

Preview

PDF
476Kb

Abstract:	The influence of neuron-adhesive pattern geometry on long-term survival of cortical neural tissue (rat brain) was studied over a time period of 15 days. Microwells (depth 0.5 /spl mu/m) with diameters of 25, 50, 100 and 150 /spl mu/m and inter-microwell distances of 15, 30, 60 and 90 /spl mu/m, were etched in a neuron-repellent fluorocarbon (FC)-layer and coated with neuron-adhesive polyethylenimine (PEI). Results showed that the survival of neural tissue was geometry-independent after 1, 4 and 8 days but was favored on 150 /spl mu/m wells after 15 days.
Item Type:	Conference or Workshop Item
Copyright:	©2001 IEEE
Faculty:	Electrical Engineering, Mathematics and Computer Science (EEMCS)
Research Group:	Biomedical Signals and Systems (BSS)
Link to this item:	http://purl.utwente.nl/publications/42182
Export this item as:	BibTeX EndNote HTML Citation Reference Manager

Show download statistics for this publication

Repository Staff Only: item control page

Metis ID: 200709