Survival of adhering cortical neurons on polyethylenimine micropatterns


Ruardij, T.G. and Goedbloed, M.H. and Rutten, W.L.C. (2001) Survival of adhering cortical neurons on polyethylenimine micropatterns. In: 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Isyanbul, Turkey (pp. pp. 749-752).

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Abstract:The influence of neuron-adhesive pattern geometry on long-term survival of cortical neural tissue (rat brain) was studied over a time period of 15 days. Microwells (depth 0.5 /spl mu/m) with diameters of 25, 50, 100 and 150 /spl mu/m and inter-microwell distances of 15, 30, 60 and 90 /spl mu/m, were etched in a neuron-repellent fluorocarbon (FC)-layer and coated with neuron-adhesive polyethylenimine (PEI). Results showed that the survival of neural tissue was geometry-independent after 1, 4 and 8 days but was favored on 150 /spl mu/m wells after 15 days.
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Copyright:©2001 IEEE
Electrical Engineering, Mathematics and Computer Science (EEMCS)
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