Heme-Protein Active Site Models via Self-Assembly in Water

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Fiammengo, Roberto and Wojciechowski, Kamil and Crego Calama, Mercedes and Figoli, Alberto and Reinhoudt, David N. and Wessling, Matthias and Timmerman, Peter (2003) Heme-Protein Active Site Models via Self-Assembly in Water. Organic Letters, 5 (19). pp. 3367-3370. ISSN 1523-7060

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Abstract:Water-soluble models of heme-protein active sites are obtained via the self-assembly of cationic porphyrins 1 and tetrasulfonato calix[4]arene 2 (K1·2 = 105 M-1). Selective binding of ligands either outside or inside the cavity of assemblies 1·2 via coordination to the zinc center has been observed. Small ligands such as 4-methylpyridine and 1-methylimidazole are encapsulated, while the bulkier caffeine is bound outside. Assemblies Co-1·2, in which the Zn porphyrin moiety has been replaced by a CoII porphyrin, can act as O2 carriers.
Item Type:Article
Copyright:© 2003 American Chemical Society
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Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/40758
Official URL:http://dx.doi.org/10.1021/ol030053w
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Metis ID: 214472