Feasibility of evanescent wave interferometer immunosensors for pesticide detection: chemical aspects

Lechuga, L.M. and Lenferink, A.T.M. and Kooyman, R.P.H. and Greve, J. (1995) Feasibility of evanescent wave interferometer immunosensors for pesticide detection: chemical aspects. Sensors and Actuators B: Chemical, 25 (1-3). pp. 762-765. ISSN 0925-4005

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Abstract:	A waveguide Mach-Zehnder Interferometer (MZI) immunosensor has been developed which can detect, in a direct way, a minimum average layer growth thickness of the analyte of 2×10−3 nm (bound mass, I′=1×10−4 δ cm−2). The design and fabrication of the sensor and the experimental set-up are aimed at decreasing the detection limit. A flow cell has been designed and incorporated into the set-up to allow a high mass-transport rate of the analyte molecules to the sensor surface, in this way decreasing the net response time. Results for the immunosystem α-hSA/hSA are presented. All improvements have been done as a first step towards the use of the MZI immunosensor in the direct detection of low coverages of pesticides with an expected layer growth of 2×10−4 nm.
Item Type:	Article
Copyright:	© 1995 Elsevier Science
Faculty:	Science and Technology (TNW)
Research Group:	Nano-Biophysics (NBP)
Link to this item:	http://purl.utwente.nl/publications/24916
Official URL:	http://dx.doi.org/10.1016/0925-4005(95)85169-0
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