Performance of a highly sensitive optical waveguide Mach-Zehnder interferometer immunosensor

Heideman, R.G. and Kooyman, R.P.H. and Greve, J. (1993) Performance of a highly sensitive optical waveguide Mach-Zehnder interferometer immunosensor. Sensors and Actuators B: Chemical, 10 (3). pp. 209-217. ISSN 0925-4005

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Abstract:	We describe a highly sensitive sensor which uses the evanescent field of a reusable planar optical waveguide as the sensing element. The waveguide used is optimized to obtain a steep dependence of the propagation velocity on the refractive-index profile near the surface. The adsorption of a layer of proteins thus results in a phase change, which is measured interferometrically using a Mach-Zehnder interferometer set-up. The stability of the interferometer is such that phase changes = (1 × 10-2)2pi per hour can be measured. Immunoreactions have been monitored down to concentrations of 5 × 10-11 M of a 40 kDa protein.
Item Type:	Article
Copyright:	© 1993 Elsevier Science
Faculty:	Science and Technology (TNW)
Research Group:	Nano-Biophysics (NBP)
Link to this item:	http://purl.utwente.nl/publications/24692
Official URL:	http://dx.doi.org/10.1016/0925-4005(93)87008-D
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