The use of self-assembled receptor layers in immunosensors


Kooyman, R.P.H. and Heuvel, D.J. van den and Drijfhout, J.W. and Welling, G.W. (1994) The use of self-assembled receptor layers in immunosensors. Thin Solid Films, 244 (1-2). pp. 913-916. ISSN 0040-6090

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Abstract:We demonstrate that a self-assembled monolayer consisting of an alkylthiol coupled synthetic peptide adsorbed to a gold substrate results in a sensitive receptor surface for specific recognition of protein molecules. The affinity constant of this binding is comparable with that of an antibody-antigen reaction. Evidence is found that such a receptor surface is capable of reversible binding.
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Copyright:© 1994 Elsevier Science
Science and Technology (TNW)
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Metis ID: 129459