Synthesis of monoalkylated calix[4]arenes via direct alkylation


Groenen, Leo C. and Ruël, Bianca H.M. and Casnati, Alessandro and Verboom, Willem and Pochini, Andrea (1991) Synthesis of monoalkylated calix[4]arenes via direct alkylation. Tetrahedron, 47 (39). pp. 8379-8384. ISSN 0040-4020

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Abstract:A new one-step procedure for the synthesis of monoalkylated calix[4]arenes is presented. Reaction of calix[4]arene 1a or 1b with 1.2 equivalent of a weak base (K2CO3 in MeCN or CsF in DMF) and excess of alkylating agent affords the monoalkylated calix[4]arenes in moderate to good yields
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Copyright:© 1991 Elsevier Science
Science and Technology (TNW)
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Metis ID: 106725