Selective functionalization of calix[6]arenes at the upper rim


Mendoza, Javier de and Carramolino, Mar and Cuevas, Felix and Nieto, Pedro M. and Prados, Pilar and Reinhoudt, David N. (1994) Selective functionalization of calix[6]arenes at the upper rim. Synthesis, 1994 (1). pp. 47-50. ISSN 0039-7881

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Abstract:Methylation of partially O-benzylated p-tert-butylcalix[6]arenes followed by hydrogenolysis constitutes an efficient method for the preparation of partially O-alkylated Calix[6]arenes in gram amounts, without adhering to column chromatography separations. Selective de-tert-butylation followed by halogenation, or ipso-nitration of these precursors affords Calix[6]arenes containing bromo- or nitrosubstituents, respectively, at precise positions of the upper rim.
Item Type:Article
Copyright:© Georg Thieme Verlag 1994
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Metis ID: 106664