"Molecular-imprinting" of AMP utilising the polyion complex formation process as detected by a QCM system

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Kanekiyo, Yasumasa and Inoue, Kazuhiko and Ono, Yoshiyuki and Sano, Masahito and Shinkai, Seiji and Reinhoudt, David N. (1999) "Molecular-imprinting" of AMP utilising the polyion complex formation process as detected by a QCM system. Journal of the Chemical Society. Perkin transactions II, 1999 (12). pp. 2719-2722. ISSN 0300-9580

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Abstract:The formation of a polyion complex was applied for molecular imprinting of AMP on a QCM resonator surface. The gold electrode on the resonator surface was modified with anionic thiols. Subsequently, layers of polycations and boronic acid-containing polyanions were adsorbed onto the QCM anionic surface utilising an alternating adsorption process. When the polymer adsorption was conducted in the presence of AMP, the anionic charges of the phosphate group introduced into polyanion by a boronate–cis-diol interaction altered the film growth behaviour: viz., excess polycationic units were adsorbed onto the polyanionic surface. After removal of the AMP from the surface polyion complex, a swollen gel layer with excess cationic charge is created. It was proven that this QCM system sensitively responds to AMP. The responsiveness is derived from the mass decrease in relation to the shrinking of the surface gel layer.
Item Type:Article
Copyright:© Royal Society of Chemistry 2008
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Link to this item:http://purl.utwente.nl/publications/11631
Official URL:http://dx.doi.org/10.1039/a905965b
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