Specific RNA dinucleotide cleavage by a synthetic calix[4]arene-based trinuclear metallo(II)-phosphodiesterase

Molenveld, Peter and Engbersen, Johan F.J. and Reinhoudt, David N. (1999) Specific RNA dinucleotide cleavage by a synthetic calix[4]arene-based trinuclear metallo(II)-phosphodiesterase. Angewandte Chemie, International Edition in English, 38 (21). pp. 3189-3192. ISSN 0570-0833

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Abstract:	Large rate enhancements and considerable nucleobase specificity in the catalytic transesterification of RNA dinucleotides are observed with the calix[4]arene enzyme mimic 1-Zn3 (the computer-generated model of the complex with GpG is shown). The higher activity toward GpG over ApA (factor of 160) originates from favorable substrate binding and cooperative catalytic action of all three ZnII ions. The heterotrinuclear metallo-phosphoesterase mimic 1-Zn2Cu is even more active.
Item Type:	Article
Copyright:	© 1999 WILEY-VCH Verlag
Faculty:	Science and Technology (TNW)
Research Group:	Biomedical Chemistry (BMC)
Link to this item:	http://purl.utwente.nl/publications/11627
Official URL:	http://dx.doi.org/10.1002/(SICI)1521-3773(19991102)38:21<3189::AID-ANIE3189>3.0.CO;2-X
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